By Eric Beitz
The aquaporin box has matured at an extremely quick speed and we're on the verge to improve critical ideas to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key must haves can be found this present day: i. a substantial (and turning out to be) variety of aquaporin crystal buildings for the rational layout of inhibitory molecules, ii. tricky molecular dynamics simulation concepts for theoretical analyses of selectivity mechanisms and docking experiments, iii. accomplished info on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological reports, and v. assay platforms for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and therefore covers the advancements from uncomplicated examine to capability pharmacological use. positioned among pharmacology textbooks and up to date medical papers this publication offers a well timed evaluate for readers from the basic in addition to the utilized disciplines.
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Aquaporins: 190 (Handbook of Experimental Pharmacology) by Eric Beitz