Download PDF by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu: Analytical Method Development and Stability Studies of

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

Master's Thesis from the 12 months 2011 within the topic drugs - Pharmacology, grade: 8.0, , path: B.Pharm.,M.Pharm, language: English, summary: A opposite part excessive functionality liquid chromatographic procedure (HPLC) has been constructed for the strategy improvement validation of Carvedilol in bulk and pharmaceutical formula by utilizing YMC PACK seasoned 4.6 X a hundred and fifty mm (5µm Particle size). The cellular section used to be Buffer: Acetonitrile: (70:30) and pH used to be adjusted to two pumped at a circulation expense of one ml/min and the eluents have been monitored at 320nm. Linearity used to be received within the focus diversity of 10-90 μg/ml. The retention time of Carvedilol used to be discovered to be 3.2 minute. the tactic used to be tested for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been came upon to be 0.001 μg/ml and 0.011μg/ml respectively. the tactic used to be statistically tested and RSD was once came across to be lower than 2% indicating excessive measure of accuracy and precision of the proposed HPLC strategy. balance examine file published that the drug is weak for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is strong to thermal degradation. extra over the degradants have been good separated from its API. as a result of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC technique can be utilized for deciding on Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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